• 四川大學(xué)華西醫(yī)院肝臟及血管外科（成都 610041）;

目的  介紹肝移植治療神經(jīng)內(nèi)分泌腫瘤肝轉(zhuǎn)移的進展。方法  收集國內(nèi)、外近年來有關(guān)肝移植治療神經(jīng)內(nèi)分泌腫瘤肝轉(zhuǎn)移的文獻并進行分析和綜述。 結(jié)果  神經(jīng)內(nèi)分泌腫瘤進展緩慢，對于不能切除的肝臟神經(jīng)內(nèi)分泌轉(zhuǎn)移瘤，經(jīng)過嚴(yán)格的臨床和病理組織學(xué)評估后實行肝移植，癥狀能夠有效地緩解甚至可能治愈。結(jié)論  選擇合適的患者，肝移植治療神經(jīng)內(nèi)分泌腫瘤肝轉(zhuǎn)移效果良好。

引用本文： 靳曙光,嚴(yán)律南. 應(yīng)用肝移植治療神經(jīng)內(nèi)分泌腫瘤肝轉(zhuǎn)移的新進展. 中國普外基礎(chǔ)與臨床雜志, 2009, 16(6): 449-451. doi: 復(fù)制

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1. Newton JN, Swerdlow AJ, dos Santos Silva IM, et al. The epidemiology of carcinoid tumours in England and Scotland [Ｊ]. Br J Cancer, 1994; 70(5): 939-942.
2. Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13 715 carcinoid tumors [Ｊ]. Cancer, 2003; 97(4): 934-959.
3. Helland SK, Prsch AM, Viste A. Carcinoid tumours in the gastrointestinal tract-a population-based study from Western Norway [Ｊ]. Scand J Surg, 2006; 95(3): 158-161.
4. Oberg K. Management of neuroendocrine tumours [Ｊ]. Ann Oncol, 2004; 15 Suppl 4: iv293-iv298.
5. Solcia E, Kloppel G, Sobin L Eds. Histological Typing of Endocrine Tumours [Ｍ]. 2nd ed. New York, USA: Springer, 2000: 38-74.
6. Makowka L, Tzakis AG, Mazzaferro V, et al. Transplantation of the liver for metastatic endocrine tumors of the intestine and pancreas [Ｊ]. Surg Gynecol Obstet, 1989; 168(2): 107-111.
7. Anthuber M, Jauch KW, Briegel J, et al. Results of liver transplantation for gastroenteropancreatic tumor metastases [Ｊ]. World J Surg, 1996; 20(1): 73-76.
8. Dousset B, Saint-Marc O, Pitre J, et al. Metastatic endocrine tumors: medical treatment, surgical resection, or liver transplantation [Ｊ]. World J Surg, 1996; 20(7): 908-914.
9. Lehnert T. Liver transplantation for metastatic neuroendocrine carcinoma: an analysis of 103 patients [Ｊ]. Transplantation, 1998; 66(10): 1307-1312.
10. Ringe B, Lorf T, Dpkens K, et al. Treatment of hepatic metastases from gastroenteropancreatic neuroendocrine tumors: role of liver transplantation [Ｊ]. World J Surg, 2001; 25(6): 697-699.
11. Lang H, Oldhafer KJ, Weimann A, et al. Liver transplantation for metastatic neuroendocrine tumors [Ｊ]. Ann Surg, 1997; 225(4): 347-354.
12. Curtiss SI, Mor E, Schwartz ME, et al. A rational approach to the use of hepatic transplantation in the treatment of metastatic neuroendocrine tumors [Ｊ]. J Am Coll Surg, 1995; 180(2): 184-187.
13. Florman S, Toure B, Kim L, et al. Liver transplantation for neuroendocrine tumors [Ｊ]. J Gastrointest Surg, 2004; 8(2): 208-212.
14. Frilling A, Malago M, Weber F, et al. Liver transplantation for patients with metastatic endocrine tumors: single-center experience with 15 patients [Ｊ]. Liver Transpl, 2006; 12(7): 1089-1096.
15. Ahlman H, Friman S, Cahlin C, et al. Liver transplantation for treatment of metastatic neuroendocrine tumors [Ｊ]. Ann N Y Acad Sci, 2004; 1014: 265-269.
16. Olausson M, Friman S, Cahlin C, et al. Indications and results of liver transplantation in patients with neuroendocrine tumors [Ｊ]. World J Surg, 2002; 26(8): 998-1004.
17. Olausson M, Friman S, Herlenius G, et al. Orthotopic liver or multivisceral transplantation as treatment of metastatic neuroendocrine tumors [Ｊ]. Liver Transpl, 2007; 13(3):327-333.
18. Rosenau J, Bahr MJ, von Wasielewski R, et al. Ki67, E-cadherin, and p53 as prognostic indicators of long-term outcome after liver transplantation for metastatic neuroendocrine tumors [Ｊ]. Transplantation, 2002; 73(3): 386-394.
19. van Vilsteren FG, Baskin-Bey ES, Nagorney DM, et al. Liver transplantation for gastroenteropancreatic neuroendocrine cancers: Defining selection criteria to improve survival [Ｊ]. Liver Transpl, 2006; 12(3): 448-456.
20. Le Treut YP, Delpero JR, Dousset B, et al. Results of liver transplantation in the treatment of metastatic neuroendocrine tumors. A 31-case French multicentric report [Ｊ]. Ann Surg, 1997; 225(4): 355-364.
21. Routley D, Ramage JK, McPeake J, et al. Orthotopic liver transplantation in the treatment of metastatic neuroendocrine tumors of the liver [Ｊ]. Liver Transpl Surg, 1995; 1(2): 118-121.
22. Le Treut YP, Grégoire E, Belghiti J, et al. Predictors of long-term survival after liver transplantation for metastatic endocrine tumors: an 85-case French multicentric report [Ｊ]. Am J Transplant, 2008; 8(6): 1205-1213.
23. Lang H, Schlitt HJ, Schmidt H, et al. Total hepatectomy and liver transplantation for metastatic neuroendocrine tumors of the pancreas-a single center experience with ten patients [Ｊ]. Langenbecks Arch Surg, 1999; 384(4): 370-377.
24. 嚴(yán)律南, 王震俠. 肝癌肝移植的適應(yīng)證及應(yīng)用前景 [Ｊ]. 中國普外基礎(chǔ)與臨床雜志, 2006; 13(2): 132-134.
25. 陸敏強, 陳規(guī)劃, 楊揚, 等. pTNM分期預(yù)測肝癌肝移植療效的臨床研究 [Ｊ]. 中國普外基礎(chǔ)與臨床雜志, 2004; 11(5): 393-395.
26. 嚴(yán)律南, 金立人, 李波, 等. 同種異體原位肝移植10例報告 [Ｊ]. 中國普外基礎(chǔ)與臨床雜志, 2000; 7(4): 231-234.
27. 徐明清, 嚴(yán)律南, 李波, 等. 肝移植治療胰腺惡性β-細(xì)胞瘤肝轉(zhuǎn)移一例 [Ｊ]. 中華外科雜志, 2008; 46(4): 319.
  1. 1. Newton JN, Swerdlow AJ, dos Santos Silva IM, et al. The epidemiology of carcinoid tumours in England and Scotland [Ｊ]. Br J Cancer, 1994; 70(5): 939-942.
  2. 2. Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13 715 carcinoid tumors [Ｊ]. Cancer, 2003; 97(4): 934-959.
  3. 3. Helland SK, Prsch AM, Viste A. Carcinoid tumours in the gastrointestinal tract-a population-based study from Western Norway [Ｊ]. Scand J Surg, 2006; 95(3): 158-161.
  4. 4. Oberg K. Management of neuroendocrine tumours [Ｊ]. Ann Oncol, 2004; 15 Suppl 4: iv293-iv298.
  5. 5. Solcia E, Kloppel G, Sobin L Eds. Histological Typing of Endocrine Tumours [Ｍ]. 2nd ed. New York, USA: Springer, 2000: 38-74.
  6. 6. Makowka L, Tzakis AG, Mazzaferro V, et al. Transplantation of the liver for metastatic endocrine tumors of the intestine and pancreas [Ｊ]. Surg Gynecol Obstet, 1989; 168(2): 107-111.
  7. 7. Anthuber M, Jauch KW, Briegel J, et al. Results of liver transplantation for gastroenteropancreatic tumor metastases [Ｊ]. World J Surg, 1996; 20(1): 73-76.
  8. 8. Dousset B, Saint-Marc O, Pitre J, et al. Metastatic endocrine tumors: medical treatment, surgical resection, or liver transplantation [Ｊ]. World J Surg, 1996; 20(7): 908-914.
  9. 9. Lehnert T. Liver transplantation for metastatic neuroendocrine carcinoma: an analysis of 103 patients [Ｊ]. Transplantation, 1998; 66(10): 1307-1312.
  10. 10. Ringe B, Lorf T, Dpkens K, et al. Treatment of hepatic metastases from gastroenteropancreatic neuroendocrine tumors: role of liver transplantation [Ｊ]. World J Surg, 2001; 25(6): 697-699.
  11. 11. Lang H, Oldhafer KJ, Weimann A, et al. Liver transplantation for metastatic neuroendocrine tumors [Ｊ]. Ann Surg, 1997; 225(4): 347-354.
  12. 12. Curtiss SI, Mor E, Schwartz ME, et al. A rational approach to the use of hepatic transplantation in the treatment of metastatic neuroendocrine tumors [Ｊ]. J Am Coll Surg, 1995; 180(2): 184-187.
  13. 13. Florman S, Toure B, Kim L, et al. Liver transplantation for neuroendocrine tumors [Ｊ]. J Gastrointest Surg, 2004; 8(2): 208-212.
  14. 14. Frilling A, Malago M, Weber F, et al. Liver transplantation for patients with metastatic endocrine tumors: single-center experience with 15 patients [Ｊ]. Liver Transpl, 2006; 12(7): 1089-1096.
  15. 15. Ahlman H, Friman S, Cahlin C, et al. Liver transplantation for treatment of metastatic neuroendocrine tumors [Ｊ]. Ann N Y Acad Sci, 2004; 1014: 265-269.
  16. 16. Olausson M, Friman S, Cahlin C, et al. Indications and results of liver transplantation in patients with neuroendocrine tumors [Ｊ]. World J Surg, 2002; 26(8): 998-1004.
  17. 17. Olausson M, Friman S, Herlenius G, et al. Orthotopic liver or multivisceral transplantation as treatment of metastatic neuroendocrine tumors [Ｊ]. Liver Transpl, 2007; 13(3):327-333.
  18. 18. Rosenau J, Bahr MJ, von Wasielewski R, et al. Ki67, E-cadherin, and p53 as prognostic indicators of long-term outcome after liver transplantation for metastatic neuroendocrine tumors [Ｊ]. Transplantation, 2002; 73(3): 386-394.
  19. 19. van Vilsteren FG, Baskin-Bey ES, Nagorney DM, et al. Liver transplantation for gastroenteropancreatic neuroendocrine cancers: Defining selection criteria to improve survival [Ｊ]. Liver Transpl, 2006; 12(3): 448-456.
  20. 20. Le Treut YP, Delpero JR, Dousset B, et al. Results of liver transplantation in the treatment of metastatic neuroendocrine tumors. A 31-case French multicentric report [Ｊ]. Ann Surg, 1997; 225(4): 355-364.
  21. 21. Routley D, Ramage JK, McPeake J, et al. Orthotopic liver transplantation in the treatment of metastatic neuroendocrine tumors of the liver [Ｊ]. Liver Transpl Surg, 1995; 1(2): 118-121.
  22. 22. Le Treut YP, Grégoire E, Belghiti J, et al. Predictors of long-term survival after liver transplantation for metastatic endocrine tumors: an 85-case French multicentric report [Ｊ]. Am J Transplant, 2008; 8(6): 1205-1213.
  23. 23. Lang H, Schlitt HJ, Schmidt H, et al. Total hepatectomy and liver transplantation for metastatic neuroendocrine tumors of the pancreas-a single center experience with ten patients [Ｊ]. Langenbecks Arch Surg, 1999; 384(4): 370-377.
  24. 24. 嚴(yán)律南, 王震俠. 肝癌肝移植的適應(yīng)證及應(yīng)用前景 [Ｊ]. 中國普外基礎(chǔ)與臨床雜志, 2006; 13(2): 132-134.
  25. 25. 陸敏強, 陳規(guī)劃, 楊揚, 等. pTNM分期預(yù)測肝癌肝移植療效的臨床研究 [Ｊ]. 中國普外基礎(chǔ)與臨床雜志, 2004; 11(5): 393-395.
  26. 26. 嚴(yán)律南, 金立人, 李波, 等. 同種異體原位肝移植10例報告 [Ｊ]. 中國普外基礎(chǔ)與臨床雜志, 2000; 7(4): 231-234.
  27. 27. 徐明清, 嚴(yán)律南, 李波, 等. 肝移植治療胰腺惡性β-細(xì)胞瘤肝轉(zhuǎn)移一例 [Ｊ]. 中華外科雜志, 2008; 46(4): 319.