邱里 1 , 何慶 2
  • 1 川北醫(yī)學院附屬醫(yī)院急診科（四川南充，637000）;2 四川大學華西醫(yī)院急診科;

【摘要】 目的  探討細菌性膠原酶對創(chuàng)口感染情況的影響。 方法  2006年11月-2006年12月，對28只新西蘭兔分為實驗組和對照組，分別予細菌性膠原酶溶液及生理鹽水浸潤創(chuàng)口并縫合。觀察創(chuàng)口感染及局部皮膚的炎性細胞浸潤情況。 結果  實驗組與對照組創(chuàng)口感染率差別無統(tǒng)計學意（P gt;0.05），炎性細胞差別無統(tǒng)計學意義（P gt;0.05）。 結論  細菌性膠原酶在創(chuàng)傷修復過程中不能直接降低感染率，對炎性細胞的遷移并無明顯的作用。 
【Abstract】 Objective  To assess the effects of bacterial collagenase on the wound infection. Methods  A total of 28 New Zealand rabbits have chosen from November to December 2006, and were divided into a laboratorial group and a control group. We sutured the wounds and soaked them by the bacterial collagenase liquid or by the physiologic saline solution. The infection and the inflammatory cells of the skin around the wound were observed. Results  The difference of the infection rates between the two groups was not statistically significant (P=0.62), nor the difference of inflammatory cells (P=0.84). Conclusions  Bacterial collagenase can not decrease the rate of infection directly, and had no obvious effect on the transferring of inflammatory cells.

引用本文： 邱里,何慶. 盲法研究細菌性膠原酶對創(chuàng)傷感染的影響. 華西醫(yī)學, 2010, 25(10): 1815-1816. doi: 復制

版權信息： ?四川大學華西醫(yī)院華西期刊社《華西醫(yī)學》版權所有，未經授權不得轉載、改編

1. Soroff HS, Sasvary DH. Collagenase ointment and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine cream in partial-thickness burns: a pilot study[J]. Burn Care Rehabil, 1994, 15(1): 13-17.
2. Ozcan C, Ergun O. Emzymatic debridement of burn wound with collagenase in children with partial-thickness burns[J]. Burns, 2002, 28, (8): 791-794.
3. Shi L, Carson D. Collagenase Santyl ointment: a selective agent for wound debridement[J]. Wound Ostomy Continence Nurs. 2009, 36(6): 12-16.
4. Ermertcan AT, Inan S, Ozturkcan S, et al. Cilaker Scomparison of the effects of collagenase and extract of Centella asiatica in an experimental model of wound healing: an immunohistochemical and histopathological study[J]. 2008, 16(5): 674-681.
5. 曲濱, 邵鐵濱, 楊心波, 等. 梭狀芽孢桿菌膠原酶治療深Ⅱ度燒傷的臨床觀察[J]. 黑龍江醫(yī)學, 2003, 27(8): 590.
6. Riley KN, Herman IM. Collagenase promotes the cellular responses toinjury and wound hea-ling in vivo[J]. Burns Wounds, 2005, 17(4): 8.
7. Eldad A, Weinberg A, Beiterman S, et al. Early nonsurgical removal of chemically injured tissue enhances wound healing in partial thickness burns[J]. Burn, 1998, 24(2): 166-172.
8. 程飚, 付小兵, 盛志勇, 等. 堿性成纖維細胞生長因子對大鼠燙傷創(chuàng)面中基質金屬蛋白及其抑制劑的影響[J]. 中華燒傷雜志, 2003, 19(6): 336-339.
9. 王世嶺, 李利根, 周亮, 等. 膠原酶對小面積深度燒傷創(chuàng)面清創(chuàng)效果分析[J]. 中國臨床藥理學雜志, 2000, 16(1): 18-21.
10. 李孝建, 劉錫麟, 霍麗貞. 愛療素軟膏對深度燒傷創(chuàng)面的療效觀察[J]. 廣東藥學報, 2000, 16(1): 65-66.
11. 楊紅明, 柴家科, 郭振榮, 等. 創(chuàng)面用藥變革對深Ⅱ度燒傷創(chuàng)面愈合時間的影響[J]. 中國修復重建外科雜志, 2001, 15(3): 162-164.
12. 王配合, 齊順貞, 彭毅志. 愛療素軟膏對深Ⅱ度燒傷創(chuàng)面的療效觀察[J]. 華北國防醫(yī)藥, 2004, 16(1): 10-12.
  1. 1. Soroff HS, Sasvary DH. Collagenase ointment and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine cream in partial-thickness burns: a pilot study[J]. Burn Care Rehabil, 1994, 15(1): 13-17.
  2. 2. Ozcan C, Ergun O. Emzymatic debridement of burn wound with collagenase in children with partial-thickness burns[J]. Burns, 2002, 28, (8): 791-794.
  3. 3. Shi L, Carson D. Collagenase Santyl ointment: a selective agent for wound debridement[J]. Wound Ostomy Continence Nurs. 2009, 36(6): 12-16.
  4. 4. Ermertcan AT, Inan S, Ozturkcan S, et al. Cilaker Scomparison of the effects of collagenase and extract of Centella asiatica in an experimental model of wound healing: an immunohistochemical and histopathological study[J]. 2008, 16(5): 674-681.
  5. 5. 曲濱, 邵鐵濱, 楊心波, 等. 梭狀芽孢桿菌膠原酶治療深Ⅱ度燒傷的臨床觀察[J]. 黑龍江醫(yī)學, 2003, 27(8): 590.
  6. 6. Riley KN, Herman IM. Collagenase promotes the cellular responses toinjury and wound hea-ling in vivo[J]. Burns Wounds, 2005, 17(4): 8.
  7. 7. Eldad A, Weinberg A, Beiterman S, et al. Early nonsurgical removal of chemically injured tissue enhances wound healing in partial thickness burns[J]. Burn, 1998, 24(2): 166-172.
  8. 8. 程飚, 付小兵, 盛志勇, 等. 堿性成纖維細胞生長因子對大鼠燙傷創(chuàng)面中基質金屬蛋白及其抑制劑的影響[J]. 中華燒傷雜志, 2003, 19(6): 336-339.
  9. 9. 王世嶺, 李利根, 周亮, 等. 膠原酶對小面積深度燒傷創(chuàng)面清創(chuàng)效果分析[J]. 中國臨床藥理學雜志, 2000, 16(1): 18-21.
  10. 10. 李孝建, 劉錫麟, 霍麗貞. 愛療素軟膏對深度燒傷創(chuàng)面的療效觀察[J]. 廣東藥學報, 2000, 16(1): 65-66.
  11. 11. 楊紅明, 柴家科, 郭振榮, 等. 創(chuàng)面用藥變革對深Ⅱ度燒傷創(chuàng)面愈合時間的影響[J]. 中國修復重建外科雜志, 2001, 15(3): 162-164.
  12. 12. 王配合, 齊順貞, 彭毅志. 愛療素軟膏對深Ⅱ度燒傷創(chuàng)面的療效觀察[J]. 華北國防醫(yī)藥, 2004, 16(1): 10-12.