• 湖北醫(yī)藥學(xué)院附屬太和醫(yī)院眼科（湖北十堰，442000）;

目的 　探討聚乙二醇滴眼液對(duì)準(zhǔn)分子激光上皮下角膜磨鑲術(shù)（LASEK）后角膜霧狀混濁（haze）影響的臨床研究。 方法 　回顧性分析2009年3月－2010年3月行LASEK的患者45例90只眼的臨床資料?；颊咔舛龋?4.68 ± 2.30）D（?1.75～?6.50 D），隨機(jī)分為聚乙二醇滴眼液組（試驗(yàn)組）和對(duì)照組，術(shù)后定期隨訪觀察兩組角膜haze形成、角膜上皮愈合時(shí)間、視力恢復(fù)情況及屈光度。 結(jié)果 　術(shù)后1、3、6個(gè)月，兩組haze形成差異無統(tǒng)計(jì)學(xué)意義（P＞0.05），試驗(yàn)組術(shù)后第1、3、5天角膜刺激癥狀明顯輕于對(duì)照組（P＜0.05），上皮愈合速度較對(duì)照組更快（P＜0.05）。 結(jié)論 　LASEK術(shù)后應(yīng)用聚乙二醇滴眼液雖然能減輕術(shù)后患者角膜刺激癥狀,能促進(jìn)角膜上皮更快愈合，但是不能減輕haze的形成。

引用本文： 譚業(yè)雙,周霞,孫斌,潘桂萍. 聚乙二醇滴眼液對(duì)準(zhǔn)分子激光上皮下角膜磨鑲術(shù)后角膜霧狀混濁形成的影響. 華西醫(yī)學(xué), 2012, 27(4): 567-569. doi: 復(fù)制

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1. 　Kornilovsky IM. Clinical results after subepithelial photorefractive keratectomy (LASEK)[J]. J Refract Surg, 2001, 17(2): 222-223.
2. 　Lee JB , Seong GJ , Lee J H , et al. Comparison of laser epithelial keratomileusis and photorefractive keratectomy for low to moderate myopia[J]. J Cataract Refract Surg, 2001, 27(4): 565-570.
3. 　譚業(yè)雙, 劉磊, 李新宇. LASEK術(shù)后Haze的發(fā)病機(jī)制與防治的研究進(jìn)展[J].眼科新進(jìn)展, 2007, 27(7): 546-548.
4. 　趙家良, 黎曉新, 董冬生, 等. 普拉洛芬滴眼液治療白內(nèi)障術(shù)后炎癥和非感染性眼前段炎癥的臨床評(píng)價(jià)[J]. 眼科研究, 2000, 18(6): 560-564.
5. 　Fantes FE, Hanna KD, Waring GO, et al. Wound healing afterexcimer laser keratomileusis (photorefractive keratectomy) in monkeys[J]. Arch Ophthalmol, 1990, 108(5): 665-675.
6. 　Camellin M.LASEK may after the advantages of both lasik and PRK[J]. Ocu Surg N Int， 1999, 10(3): 14-15 .
7. 　Scerrati E. Laser in situ keratomileusis vs laser epithelial keratomileusis (LASIK vs LASEK) [J]. J RefractSurg, 2001, 17(2): 219-221.
8. 　Hersh PS, Stulting RD, Steinert RF, et al. Results of Phase Ⅲexcimer laser photorefractive keratectomy for myopia; the Summit PRK Study Group[J]. Ophthalmology, 1997, 104(10): 1535-1553.
9. 　 Kremer I, Kaplan A, Novikov I, et al. Patterns of late corneal scarring after photorefractive keratectomy in high and severe myopia[J]. Ophthalmology, 1999, 106(3): 467-473.
10. 　Cua IY, Pepose JS. Late corneal scarring after photorefractive keratectomy concurrent with the development of systemic lupus erythematosus[J]. J Refract Surg, 2002, 18(6): 750-752.
11. 　Stojanovic A, Nitter TA. Correlation between ultraviolet radiation level and the incidence of late-onset corneal haze after photorefractive keratectomy[J]. J Cataract Refract Surg, 2001, 27(3): 404-410.
12. 　Mocanu C, Bǎrǎscu D, B rjovanu F, et al. Assessment of systane in severe dry eye[J]. Oftalmologia, 2008, 52(1): 105-110.
13. 　Gifford P, Evans BJ, Morris J. A clinical evaluation of Systane[J]. Cont Lens Anterior Eye, 2006, 29(1): 31-40.
14. 　David K. A two-week clinical evaluation of the safety of systane ultra in contact lens-wearing patients [J]. Clin Ophthalmol, 2010, 4(2): 27-32.
15. 　Wang MX, Gray TB, Clan PW, et al. Reduction in corneal haze apoptosis by amniotic membrane matrix in excimer laser photo ablation in rabbits[J]. J Caratact Refract Surg, 2001, 27(2): 310 -319.
16. 　Netto MV, Mohan RR, Ambrósio R Jr, et al.Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy[J]. Cornea, 2005, 24(5): 509-522.
  1. 1. 　Kornilovsky IM. Clinical results after subepithelial photorefractive keratectomy (LASEK)[J]. J Refract Surg, 2001, 17(2): 222-223.
  2. 2. 　Lee JB , Seong GJ , Lee J H , et al. Comparison of laser epithelial keratomileusis and photorefractive keratectomy for low to moderate myopia[J]. J Cataract Refract Surg, 2001, 27(4): 565-570.
  3. 3. 　譚業(yè)雙, 劉磊, 李新宇. LASEK術(shù)后Haze的發(fā)病機(jī)制與防治的研究進(jìn)展[J].眼科新進(jìn)展, 2007, 27(7): 546-548.
  4. 4. 　趙家良, 黎曉新, 董冬生, 等. 普拉洛芬滴眼液治療白內(nèi)障術(shù)后炎癥和非感染性眼前段炎癥的臨床評(píng)價(jià)[J]. 眼科研究, 2000, 18(6): 560-564.
  5. 5. 　Fantes FE, Hanna KD, Waring GO, et al. Wound healing afterexcimer laser keratomileusis (photorefractive keratectomy) in monkeys[J]. Arch Ophthalmol, 1990, 108(5): 665-675.
  6. 6. 　Camellin M.LASEK may after the advantages of both lasik and PRK[J]. Ocu Surg N Int， 1999, 10(3): 14-15 .
  7. 7. 　Scerrati E. Laser in situ keratomileusis vs laser epithelial keratomileusis (LASIK vs LASEK) [J]. J RefractSurg, 2001, 17(2): 219-221.
  8. 8. 　Hersh PS, Stulting RD, Steinert RF, et al. Results of Phase Ⅲexcimer laser photorefractive keratectomy for myopia; the Summit PRK Study Group[J]. Ophthalmology, 1997, 104(10): 1535-1553.
  9. 9. 　 Kremer I, Kaplan A, Novikov I, et al. Patterns of late corneal scarring after photorefractive keratectomy in high and severe myopia[J]. Ophthalmology, 1999, 106(3): 467-473.
  10. 10. 　Cua IY, Pepose JS. Late corneal scarring after photorefractive keratectomy concurrent with the development of systemic lupus erythematosus[J]. J Refract Surg, 2002, 18(6): 750-752.
  11. 11. 　Stojanovic A, Nitter TA. Correlation between ultraviolet radiation level and the incidence of late-onset corneal haze after photorefractive keratectomy[J]. J Cataract Refract Surg, 2001, 27(3): 404-410.
  12. 12. 　Mocanu C, Bǎrǎscu D, B rjovanu F, et al. Assessment of systane in severe dry eye[J]. Oftalmologia, 2008, 52(1): 105-110.
  13. 13. 　Gifford P, Evans BJ, Morris J. A clinical evaluation of Systane[J]. Cont Lens Anterior Eye, 2006, 29(1): 31-40.
  14. 14. 　David K. A two-week clinical evaluation of the safety of systane ultra in contact lens-wearing patients [J]. Clin Ophthalmol, 2010, 4(2): 27-32.
  15. 15. 　Wang MX, Gray TB, Clan PW, et al. Reduction in corneal haze apoptosis by amniotic membrane matrix in excimer laser photo ablation in rabbits[J]. J Caratact Refract Surg, 2001, 27(2): 310 -319.
  16. 16. 　Netto MV, Mohan RR, Ambrósio R Jr, et al.Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy[J]. Cornea, 2005, 24(5): 509-522.